Reconstruction of compressed air pipe network in pharmaceutical workshop

Repair and transformation of the compressed air pipe network in the pharmaceutical workshop Wang Xiuhong, Jin Donghui (Tianjin Tianshili Pharmaceutical Co., Ltd., Tianjin 300000. The effect after the transformation is very good, meeting the special needs of the production of compressed air for pharmaceutical production.

Circulation pipe network: T-515: B Our company is a pharmaceutical manufacturer. With the expansion of production scale, the automation level and quantity of equipment are rapidly increasing. The flow, pressure and cleanliness of compressed air are required to meet GMP standards. Requirements.

The original compressed air supply system has reduced the efficiency of the equipment due to the supporting problems with the development of the later production scale and the defects in the design and installation, and poses a potential threat to the safety of the production of the medicine.

First, the problem of compressed air system The original compressed air supply system has the following problems: insufficient gas supply, unstable pressure, equipment can not operate normally.

The dew point temperature of compressed air exceeds the standard dew point temperature of compressed air, and the system has a large amount of water, which leads to a decline in product quality and production capacity, and an increase in equipment failure rate. The emulsion formed by the contact of moisture and oil in the compressed gas has a center of a decay axis. Then, 62 semi-circular guide rails are processed by graphite nylon and mounted on the intermediate plane of the trough-shaped steel plate by screws. The outer circle position of the guide rail is flat with the top of the original tooth-shaped shaft (such as b), so that two adjacent semi-circular guide rails jointly carry one. Flat top chain.

The drive sprocket and eccentric wheel are changed to the open-edge clip-on structure, which can be replaced independently, saving time and labor. In general, the replacement cycle of the drive sprocket and the eccentric is 1 year.

The change of the driven shaft from the rotating flat-top sprocket form to the fixed semi-circular guide form not only reduces bearing maintenance but also achieves a zero failure rate. In addition, the semi-circular guide rail can be replaced as a consumable part, saving spare parts costs and manpower.

Received in the late period of 2006-02-15 corrosive, destroying the effect of oil lubrication and heat dissipation, resulting in component damage. Moisture also assists oxygen to accelerate the oxidation of the part.

The cleanliness requirements of compressed air for pharmaceutical production should reach 100,000 standards. We sampled and measured in the pipeline system. The results were qualified for CO, C2, odor, pollutants, etc., but the number of dust particles was not ideal.

In order to improve the gas quality, a large number of filters have to be installed at the gas terminal, so that the maintenance workload and the cost of spare parts are greatly increased. In order to solve the problem better, we have made this an important issue and initiated the transformation of the compressed air system.

Second, the reasons for the instability of the pressure and the lack of gas volume and the reasons for the unstable pressure and the lack of gas volume. The system's pressure instability and insufficient gas volume are interrelated, and the essence is the pressure problem.

Our company's compressed air station is currently equipped with three screw air compressors. During normal production, two units are intermittently operated, one for standby; one for intermittent operation when the gas consumption is small, and two for standby. According to observations, the outlet pressure of the gas supply station has never been lower than 0.72 MPa, indicating that the gas production capacity of the unit is sufficient. Therefore, the cause of the unstable air pressure and insufficient air volume can be inferred to be caused by the unreasonable design of the gas delivery pipe network. ) Random tapping, walking around, without the level of main, branch and secondary pipelines, is not conducive to pipe network management, reasonable gas diversion and system pressure balance. The main pipe diameter is too small, and other branches are arbitrarily enlarged or reduced; too many end filters increase the system pressure drop; mixed flow occurs at the joints, etc., which adversely affect the stability of the air pressure.

Repair and Reconstruction WW阖丨Ml) The piping system does not have the necessary control valve installed, which is not conducive to system partition control and overhaul. In the pipeline system, except for the upstream compressed air station, which has a gas storage tank, the intermediate link is not configured. ) Redesign the pipe network. In the transformation, the entire pipe network system is designed as a three-stage ring pipe network (for example). The first level, the main line surrounds the entire plant; the second level is divided into three parts according to the plant area, each part forms a secondary loop; the third stage, each used gas point is taken by the secondary loop near the point. . In this way, two-way air supply can be obtained at any position. If a certain amount of air consumption suddenly increases, it can be quickly replenished to reduce pressure fluctuations. ) Re-select the pipe diameter of each stage while shortening the stroke of the pipeline, reducing the sudden change of the elbow and the pipe diameter, thereby reducing the pressure loss. In addition to the gas storage tank of the original compressed air station, a gas storage tank is installed in each secondary pipeline system to ensure smooth pipeline pressure and reduce the number of loading or unloading of the compressor unit.

Third, the cause and countermeasures of the dew point temperature exceeding the standard 1. Reasons for the excessive dew point) The post-processing process of the original compressed air station is: air compressor unit! High efficiency degreaser! No heat regeneration drying treatment! Deodorization filter! Dust filtration! gas tank! Pipe network system. Except for the non-thermal regeneration drying and gas storage tanks, which can partially remove water, there is no other water-discharging and water-removing facilities, and it is easy to have the problem of large moisture content of compressed air and fast rise of dew point. There are few condensate and drainage devices in the center of the pipeline system, and the condensed water in the pipeline cannot be effectively removed in time; there is no suitable height difference in the overall arrangement of the pipeline, which is not conducive to the discharge of condensed water. A large number of branch pipes are not installed according to the specifications when the taps are tapped, and some are directly opened from the bottom of the main pipe, which easily causes the condensed water to directly flow into the gas point. ) Redesign the post-treatment process of the compressed air station. Add freeze drying and precision filtration to change the original process to: air compressor unit! High efficiency degreaser! gas tank! Freeze dryer! No heat regeneration drying treatment! Deodorization filter! Precision filter! Dust filtration! Precision filter! Pipe network system.

In this configuration, the gas storage tank can filter part of the condensed water, and the gas storage tank also has the function of lowering the gas temperature. Air with low temperature and low water content enters the freeze dryer, which can reduce the load on the dryer or filter and ensure the treatment effect.

Design collection water discharge points at low points. Install stainless steel water collector to collect and discharge condensed water to achieve effective water analysis and timely drainage. The installation of the pipelines at all levels is carried out according to the specifications, and the branch pipelines are taken out from the top of the main pipeline.

The GMP drug manufacturing regulations do not have detailed standards for compressed air. We calculate the compressed air as a normal-pressure air under standard conditions, and then purify the air quality requirements of the 100,000-class clean room according to GMP. According to the standard, the number of compressed air dust particles before the transformation exceeded the standard, because the control of the dust particles failed to start from the source.

The original pipelines are ordinary seamless carbon steel pipes, which are gradually rusted to generate dust particles when conveying compressed air with a large water content, which is the problem.

The solution to this problem is: (1) all pipes are made of stainless steel seamless pipe; (2) the compressed air station is equipped with a precision filter, and the cleaning is replaced regularly; (3) the water content of the gas is reduced, and the condensed water is discharged in time.

After the system was rebuilt for half a year, the effect was good. The performance was as follows: (1) Elimination of system pressure fluctuations and sudden “dropout” in some areas; (2) Insufficient gas consumption and pressure increase below the loading point Basically, there is no such thing; (3) The water content in the air pressure gas is obviously reduced, the dew point is reduced, and the pipeline system is reduced from 10 kg of water to less than 1 kg on average 8 h before the transformation, and many times, no water is precipitated; (4) by the quality inspection department, Compressed air cleanliness has reached the MP 100,000 clean room standard.

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